主な研究実績

Involvement of inducible nitric oxide synthase in cardiac dysfunction with tumor necrosis factor-alpha.
Funakoshi H, Kubota T, Machida Y, Kawamura N, Feldman AM, Tsutsui H, Shimokawa H, Takeshita A.
Am J Physiol Heart Circ Physiol. 2002

Disruption of inducible nitric oxide synthase improves beta-adrenergic inotropic responsiveness but not the survival of mice with cytokine-induced cardiomyopathy.
Funakoshi H, Kubota T, Kawamura N, Machida Y, Feldman AM, Tsutsui H, Shimokawa H, Takeshita A.
Circ Res. 2002

Regulated overexpression of the A1-adenosine receptor in mice results in adverse but reversible changes in cardiac morphology and function.
Funakoshi H, Chan TO, Good JC, Libonati JR, Piuhola J, Chen X, MacDonnell SM, Lee LL, Herrmann DE, Zhang J, Martini J, Palmer TM, Sanbe A, Robbins J, Houser SR, Koch WJ, Feldman AM.
Circulation. 2006

A1 adenosine receptor upregulation accompanies decreasing myocardial adenosine levels in mice with left ventricular dysfunction.
Funakoshi H, Zacharia LC, Tang Z, Zhang J, Lee LL, Good JC, Herrmann DE, Higuchi Y, Koch WJ, Jackson EK, Chan TO, Feldman AM.
Circulation. 2007

Cardiac-restricted overexpression of the A(2A)-adenosine receptor in FVB mice transiently increases contractile performance and rescues the heart failure phenotype in mice overexpressing the A(1)-adenosine receptor.
Funakoshi H, Chan TO, Song J, Zhang XQ, Wang J, Chung PH, DeGeorge BR Jr, Li X, Zhang J, Herrmann DE, Diamond M, Hamad E, Houser SR, Koch WJ, Cheung JY, Feldman AM.
Clin Transl Sci. 2008

Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure.
Lymperopoulos A, Rengo G, Funakoshi H, Eckhart AD, Koch WJ.
Nat Med. 2007

Overexpression of tumor necrosis factor-alpha increases production of hydroxyl radical in murine myocardium.
Machida Y, Kubota T, Kawamura N, Funakoshi H, Ide T, Utsumi H, Li YY, Feldman AM, Tsutsui H, Shimokawa H, Takeshita A.
Am J Physiol Heart Circ Physiol. 2003

Cardiac S100A1 protein levels determine contractile performance and propensity toward heart failure after myocardial infarction.
Most P, Seifert H, Gao E, Funakoshi H, Volkers M, Heierhorst J, Remppis A, Pleger ST, DeGeorge BR Jr, Eckhart AD, Feldman AM, Koch WJ.
Circulation. 2006

Identification of candidate long noncoding RNAs associated with left ventricular hypertrophy.
Zhang L, Hamad EA, Vausort M, Funakoshi H, Feldman AM, Wagner DR, Devaux Y.
Clin Transl Sci. 2015

Whole transcriptome microarrays identify long non-coding RNAs associated with cardiac hypertrophy.
Zhang L, Hamad EA, Vausort M, Funakoshi H, Nicot N, Nazarov PV, Vallar L, Feldman AM, Wagner DR, Devaux Y; Cardiolinc network (www.cardiolinc.org).
Genom Data. 2015

Cardioprotection afforded by NF-kappaB ablation is associated with activation of Akt in mice overexpressing TNF-alpha.
Higuchi Y, Chan TO, Brown MA, Zhang J, DeGeorge BR Jr, Funakoshi H, Gibson G, McTiernan CF, Kubota T, Jones WK, Feldman AM.
Am J Physiol Heart Circ Physiol. 2006

Effects of cardiac-restricted overexpression of the A(2A) adenosine receptor on adriamycin-induced cardiotoxicity.
Hamad EA, Li X, Song J, Zhang XQ, Myers V, Funakoshi H, Zhang J, Wang J, Li J, Swope D, Madonick A, Farber J, Radice GL, Cheung JY, Chan TO, Feldman AM.
Am J Physiol Heart Circ Physiol. 2010

Controlled and cardiac-restricted overexpression of the arginine vasopressin V1A receptor causes reversible left ventricular dysfunction through Gαq-mediated cell signaling.
Li X, Chan TO, Myers V, Chowdhury I, Zhang XQ, Song J, Zhang J, Andrel J, Funakoshi H, Robbins J, Koch WJ, Hyslop T, Cheung JY, Feldman AM.
Circulation. 2011

Left ventricular dysfunction in murine models of heart failure and in failing human heart is associated with a selective decrease in the expression of caveolin-3.
Feiner EC, Chung P, Jasmin JF, Zhang J, Whitaker-Menezes D, Myers V, Song J, Feldman EW, Funakoshi H, Degeorge BR Jr, Yelamarty RV, Koch WJ, Lisanti MP, McTiernan CF, Cheung JY, Bristow MR, Chan TO, Feldman AM.
J Card Fail. 2011

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